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[2] The MHRA Drug Safety Update (August 2022) advises healthcare professionals to consider testing vitamin B12 levels in patients taking metformin who develop symptoms of neuropathy or anaemia, and to consider periodic monitoring in those at risk of deficiency

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This process is natural and happens to everyone, but some people may be more likely to experience it due to frequent activity or degenerative disease

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134 It should be also emphasized that the activation conditions in vitro do not reflect the in vivo situation where weaker cell stimulation and lower substrate availability occur

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