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Yet, in an unrandomized and unblinded trial in patients with multiple myeloma, the administration of SRT501 was associated with a number of serious adverse effects, including kidney failure, such that the trial was halted (77)

It has been concluded that there is a direct correlation between semen quality and serum 25(OH) vitamin D levels in men and vitamin D receptors (VDRs) are importantly lower in infertile men compared to other men (Reference Tremellen and Pearce54)