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showed that changes in SDC-1 mechanical tension generate a tension gradient in SDC-1 under fluid shear force, with SDC-1 interacting differently with the cytoskeleton depending on substrate stiffness, affecting integrin-mediated signaling and focal adhesion formation [49]

Peak hepatic injury occurs at 35 days after the toxic ingestion, and hepatic encephalopathy may be evident at this time, along with acute, oliguric renal failure (mechanism unclear), and lactic acidosis (from reduced hepatic clearance) (3)

References Novo Nordisk presents phase 3 data for next-generation amylin cagrilintide, leading to advancement into dedicated clinical Programme, 16 September 2025, Novo Nordisk, DAscanio AM, Mullally JA, Frishman WH

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[DOI] [PubMed] [Google Scholar] Boban Blagaic A, Turcic P, Blagaic V, et al

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