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Diluting to 2:1 (2 mL per 10 mg) drops osmolarity to approximately 280320 mOsm/L, near-isotonic with interstitial fluid, which reduces post-injection stinging by 6070% based on user-reported pain scores

doi:10.1126/science.291.5512.2364

Handheld dynamometry (HHD) has been studied and consists of the evaluator applying confrontational resistance to prespecified muscle groups, measuring outputs against healthy population Z -scores and combining Z -scores into cumulative scores for an extremity