what is glutathione used for in ecoli the Biosynthesis of Glutazoline Teredinibactins JCI Insight - Mucosal metabolites

Since NRF2 activation induces the antioxidant and detoxifying response to restore redox homeostasis state, in recent years there has been a growing interest in identifying and evaluating new compounds capable of targeting the KEAP1-NRF2 system, to induce cytoprotective response against OS

Venter H, Genade S, Mouton R, Huisamen B, Harper IS, Lochner A

10.1038/s41586-020-2124-0 126 KandasamyP.GyimesiG.KanaiY.HedigerM

El-Lakkany reported that SL could be a convenient and promising therapeutic agent in the treatment of schistosomal liver fibrosis by downregulating content of hydroxyproline, serum levels and hepatic expression of TGF-b1 and MMP-2 and the number of mast cells (El-Lakkany et al., 2012)

doi: 10.3390/separations9070165 355 ThomsonCGarciaALEdwardsCA

We frame this complexity through the concept of proteostasis resilience, defined as the ability of cells and tissues to maintain proteome stability under stress, and use it to unify disease mechanisms with therapeutic opportunity