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Mechanisms of manganese-induced neurotoxicity and the pursuit of neurotherapeutic strategies

Fedorowicz A, Mateuszuk , Kopec G, Skrka T, Kutryb-zajc B, Zakrzewska A, Walczak M, Jakubowski A, omnicka M, Somiska E, Chlopicki S (2016) Activation of the nicotinamide N -methyltransferase (NNMT)-1-methylnicotinamide (MNA) pathway in pulmonary hypertension

Sevier, C.S., Kadokura, H., Tam, V.C., Beckwith, J., Fass, D., and Kaiser, C.A

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These microbial shifts trigger cascading gutbrain disruption by impairing neurotransmitter signaling, suppressing SCFA production, weakening epithelial barrier integrity, and activating neuroimmune pathways, ultimately resulting in anxiety- and depression-like behaviors in rodent models (Tejkalov et al., 2023

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