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How JAK Inhibitors Are Used Topical JAK inhibitors (like ruxolitinib) are applied directly to affected skin areas, making them more suitable for localized vitiligo

Biomedicines 12:2167

Upon ligand binding, this presumably membrane-bound receptor transduces intracellular chemical/redox signals that relay messages for the regulation of gene expression, a phenomenon mainly involving the activation of transcription factors [2, 13, 14, 1618, 26, 34, 51, 70]

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