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6a), leading to a greater weight loss (Fig

E.Plemenita IljeA.DolanV

Biochem 28 , 229238 (2011)

The engagement of the PD-1 receptor with PD-L1 activates PD-1 downstream from Src homology region 2 domain-containing protein tyrosine phosphatase (SHP-2) and dephosphorylates ZAP70, leading to the inhibition of T cell survival, proliferation and cytokine production, inducing T-cell exhaustion

Stem Cells 30:11441151 Suzuki M, McHugh J, Tork C et al (2007) GDNF secreting human neural progenitor cells protect dying motor neurons, but not their projection to muscle, in a rat model of familial ALS