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All u SOD1 variants had K D values greater than u SOD1 WT (9 1 nM), implying that these single residue substitutions are sufficient to disturb the quaternary structure (Table 1)

Hirsch FR, Varella-Garcia M, Bunn PA, Di Maria MV, Veve R, Bremnes RM, et al

Parkin ubiquitinates phosphoglycerate dehydrogenase to suppress serine synthesis and tumor progression

Homeostatic control of water balance

Glutamate-cysteine ligase protects cells from ferroptosis by decreasing glutamate levels, converting them to -glutamyl peptides, and boosting GSH production (36) ( Figure 1 )