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Hua, Z., Frohlich, K.M., Zhang, Y., Feng, X., Zhang, J

797 Even neonatal rat ventricular muscle cells with low sensitivity to GPX4 inhibition underwent ferroptosis in the presence of cysteine deprivation, suggesting that inhibition of GPX4 promotes ferroptosis of cardiomyocytes under metabolic stress, such as cysteine deprivation

While GABAergic drugs (e.g., baclofen, bumetanide, homotaurine) show promise in preclinical models for ameliorating ASD-like behaviors, clinical translation remains limited by inconsistent efficacy and safety profiles

Leydig cells in the testes are responsible for testosterone production, and their senescence contributes to the age-related decline in testosterone levels (Zhang et al., 2020)

In this analysis, nebulized GLY improved lung function and health status in patients irrespective of comorbidity count, supporting the use of nebulized GLY among patients with COPD and comorbidities in clinical practice

Future perspective and clinical translation Overcoming current limitations Although cannabinoids hold significant promise in cancer therapy, several challenges must be overcome to enable their successful clinical application