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Wortley PM, Husten CG, Trosclair A, Chrismon J, Pederson LL

The emphasis remains on balance, texture, and construction rather than strength or intensity

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And because nicotine readily crosses the blood-brain barrier, it is also absorbed by tissues in the brain

Who it's for: Vapers who enjoy sweet flavors but still want the underlying taste of tobacco

Separate DerSimonian and Laird random-effects meta-analyses were conducted for smoking abstinence and smoking reduction because clinical and methodological heterogeneity was expected across CBT protocols, populations, comparator intensity, and follow-up definitions 13