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To advance our understanding, investigating the relocation of glutathione, both between different cell regions and its dynamic changes, along with gathering transcriptional data specifically focused on glutathione metabolism, will be crucial

Because transdermal administration necessitates passing through the hydrophobic/lipophilic SC, absorption in the deep aqueous layers, and then passage into the systemic circulation, these substances also need to have a moderate lipophilicity/hydrophilicity balance (logP = 15) [73,150,153]

In Drosophila melanogaster , the peptide reduced mitochondrial and cytosolic ROS levels, along with lipid peroxidation markers such as Schiff bases and hydroperoxides

Gilron I, Bailey JM, Tu D, Holden RR, Jackson AC, Houlden RL

doi: 10.1371/journal.pone.0189141 105 HoriiT.SuzukiS.TakanoC.ShibuyaH.IchijimaR.KusanoC.et al

Due to its extensive biological roles, spermidine is used to reduce inflammatory responses (Mao et al., 2023), improve cardiovascular health (Wu et al., 2022), and enhance cognitive functions (Pekar et al., 2021)