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Fibroblasts and endothelial cells also significantly influence pigmentation, with fibroblasts affecting melanocyte proliferation and pigmentation through MAPK and WNT/-catenin pathways, while endothelial cells stimulate and inhibit pigmentation

23 Further high-quality studies are needed to confirm the results of this RCT with appropriate enrollment and follow-up of a validated outcome in a generalizable setting

demonstrated that the intravitreal injection of synthetic melanin-like nanoparticles can clear free radicals, with reduced ROS production in RPE cells, finally alleviate the vascular leakage and show the anti-angiogenic activity in an AMD-like model

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The latest EUGOGO guidelines recommend a 6-month selenium supplementation for patients with mild and active TED of recent onset, because it improves eye manifestations and prevents progression to more severe forms [90]

121 WangY.YeM