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### AOD-9604 Mechanism of Action AOD-9604 is believed to promote **fat loss** through: - Stimulation of lipolysis in adipose tissue via beta-3 adrenergic receptor pathways - Inhibition of lipogenesis (new fat formation) - No effect on growth hormone receptors (does not promote tissue growth) - No effect on IGF-1 levels or blood glucose Importantly, AOD-9604 does **not** suppress appetite or affect food intake it is purely a lipolytic **fat loss peptide**

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For example, they are more likely to be depressed, and they have a more chronically activated hypothalamic-pituitary-adrenal axis

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To what extent systemic infusion of anti-CD20 monoclonal antibodies may deplete B cells or CD20-expressing T cells (Sabatino et al., 2019

Sun, J., Feng, Q., He, Y., Wang, M