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Patients in this cluster showed higher rates of nearly every queried symptom and comorbidity than other clusters, and as expected, the most prevalent symptoms are the core symptoms of the disorder: fatigue (98.9%), PEM (97.4%), brain fog (93.6%), unrefreshing sleep (95.2%), memory problems (82.4%), feeling of weakness (87.3%), sore/painful muscles (87.0%), insomnia (76.1%), and headache/migraine (79.8%)

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Insulin-like growth factor-1 receptor-mediated inhibition of A-type K(+) current induces sensory neuronal hyperexcitability through the phosphatidylinositol 3-kinase and extracellular signal-regulated kinase 1/2 pathways, independently of Akt