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Although it is beyond the scope of our analysis to explain precisely why we see this plateau, we offer some possible explanations

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Denoting the rsfMRI data of one voxel by x = [ x 1 , x 2 , , x N ], where N is the number of acquisitions, SampEn calculation starts with forming a series of vector sequences, each with m consecutive points extracted from x : u i = [ x i , x i +1, , x i + m 1], where i = 1( N m + 1), and m is the pre-defined window size (3, as stated above)

They are convenient, hygienic, and eliminate the need for cleaning or maintenance

Nicotine is an 'addictive poisonous chemical' that is found in tobacco

Nicotine can stimulate the neuronal release of dopamine and endogenous opioid peptides and activate the reward center of the brain