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R 2 is selected from the group consisting of: hydrogen, -CH(R a )OPO(OH)2, -CO-Y, -t-PO(OY) 2 , +PO(OH) 2 , -C(=0)-Y, -CO-U, -C(=0)-(CH 2 )rU, and -CH2-V, where R a is hydrogen or CH3, where Y is -Z-(CH2)q-W-R b , q is 0-4, where Z and W are independently selected from the group consisting of: CH2, O, S, R C and R b , where R c is selected from the group consisting of: hydrogen, C1-C4 alkyl, and C3-C6 cycloalkyl, R b is selected from the group consisting of: hydrogen, C1-C12 alkyl, C1-C12 substituted alkyl, C1-C12 alkenyl, C1-C12 substituted alkenyl, C1-C12 alkynyl, C1-C12 substituted alkynyl, C3-C8 cycloalkyl, C3-C8 substituted cycloalkyl, C6-C10 aryl, C6-C10 substituted aryl, C3-C8 heterocycloalkyl, C3-C8 substituted heterocycloalkyl, C4-C10 heteroaryl, and C4-C10 substituted heteroaryl, where r is 0-5, U is selected from aryl, heteroaryl or heterocycloalkyl, where V is -0-C(=0)-Q-(CH2)r-R d , where Q is selected from the group consisting of: a bond, O, and N(R C ), where R d is selected from the group consisting of: C6-C10 aryl, C4-C10 heteroaryl, C3-C8 heterocycloalkyl, a hexose, a pentose, and - (5-methyl-2-oxo-l,3-dioxol-4-yl)methyl), or alternatively -C(=0)-Y forms an amide bond thru a nitrogen atom on Y in which case Y is a selected from the group consisting of: glycine, sarcosine, ,-diemthyl glycine, alanine, valine, leucine, isoleucine, lysine, ornithine, arigine, serine, and theronine
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The agency would have to solicit public comment and an advisory committee of health and pharmacy experts would have to review the FDAs research
Treatment Duration 30 45 mins Results in 0 2 weeks Longevity 6 9 months Number of Sessions 2 3 sessions Deep Hydration Improves skin moisture and radiance Collagen Stimulation Strengthens and firms the skin over time Elasticity Boost Enhances skin resilience and flexibility Fine Line & Wrinkle Reduction Softens the appearance of ageing signs Skin Texture Improvement Helps with scars, sun damage, and dullness Minimal Downtime A safe, non-invasive treatment with little recovery time Polynucleotides are injected into targeted areas of the skin, where they stimulate fibroblaststhe key cells responsible for collagen and elastin production
Bozorg, S
Patients experiencing significant gastrointestinal side effects may benefit from temporary dose reduction or slowing the titration schedule