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doi:10.1002/mabi.202100257 29

In combined B12 and folate deficiency, B12 replacement must be started before folate supplementation to avoid precipitating or worsening neurological damage

10.1155/2013/180839 63 WangD.PanW

Thus, intranasal formulations should be carefully balanced with safety considerations and clinical success, rather than relying heavily on permeation enhancers to achieve effective, well-tolerated therapy (Qiu et al., 2025)

Long-term health issues related to heavy alcohol use: Chronic high BAC levels can lead to serious health problems, including liver disease, brain damage, and heart problems