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MASLD-induced changes in antioxidant system To survive in an oxygen-rich environment, aerobic organisms had to develop efficient defense systems of enzymatic and non-enzymatic antioxidants to control the cellular levels of ROS to maintain redox homeostasis (Miao and St Clair 2009

J 10 (4), 390397

Impact of ROS on the TME The TME is a complex ecosystem composed of tumor cells, immune cells, stromal cells, and various soluble factors, playing a central role in tumor initiation, progression, and treatment resistance [177]