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The diversity in the responses of individuals is the main reason for this

doi:10.7759/cureus.29583

Mutations in the tetramer interface of human glucose6phosphate dehydrogenase reveals kinetic differences between oligomeric states

Combined with activity-based protein profiling (ABPP), this approach accelerated DUBi development, leading to the identification of a covalent inhibitor of the understudied DUB VIPCP1 with nanomolar potency 163