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In contrast, RMS13 rhabdomyosarcoma cells that overexpress HRAS, KRAS, or NRAS are resistant to erastin and RAL3 (Schott et al., 2015), which means RAS does affect erastin sensitivity, while the oncogenic RAS pathway is not the sole determinant of ferroptosis sensitivity (Dixon and Stockwell, 2019)

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OS extract leads to a reduction in intracellular calcium levels and subsequent relaxation via ion influx inhibition through VOCC, as the nifedipine action, and reduces vasoconstriction caused by phenylephrine, demonstrating its involvement in IP3 and/or ryanodine receptors