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Antioxidant Activity As a powerful antioxidant, glutathione helps combat oxidative stress, which is linked to chronic diseases, aging, and inflammation

In addition to being administered as a drug to cause oxidative stress, MTX has also been used to induce cachexia, anorexia, intestinal mucositis and digestive absorption problem in experimental animal models (Reference Boukhettala, Leblond and Claeyssens34Reference Sinno, Coquerel and Boukhettala36)

The hemolysis-derived heme could initiate inflammatory OxS that may cause microvascular thrombosis, organ ischemia and MODS in severe COVID-19 102,105

Safety Considerations and Potential Drug-Nutrient Interactions Glutathione is generally well tolerated orally or intravenously, but bioavailability of oral glutathione is limited without specialized delivery forms