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In the USP11 knockout mouse model of renal fibrosis, the degradation of EGFR was increased, which inhibited downstream signaling pathways and delayed the renal fibrosis and epithelial-mesenchymal transition[54]

Pilot clinical study on SLE patients showed the replenishment of intracellular glutathione using NAC reduce oxidation of lipid, protein and DNA and improved organ damage in SLE patients

doi: 10.3389/fnut.2023.1168049 Received 17 February 2023 Accepted 03 April 2023 Published 28 April 2023 Volume 10 - 2023 Edited by Ftima Martel, University of Porto, Portugal Reviewed by Wuyang Huang, Jiangsu Academy of Agricultural Sciences (JAAS), China