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methotrexate is a folic acid antagonist that can cause mucosal, gastrointestinal, hepatic or hematologic side effects) (Brion, Lambs, and Berthon 1985

Food and Drug Administration (FDA) warnings for these medications have further ignited this fear of prescribing

The pathophysiology of migraine is complex, but the treatment of migraine may be broken down fairly broadly into several categories

Yin H, Ma YL, Deng Y, Xu ZB, Liu JY, Zhao JF, Dong JJ, Yu JH, Chang ZM (2016) Genome shuffling of Saccharomyces cerevisiae for enhanced glutathione yield and relative gene expression analysis using fluorescent quantitation reverse transcription polymerase chain reaction

Cancer 16 , 111 (2017)

This approach provides high local levels of the peptides at the target tissue while also allowing for systemic distribution