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A diagnosis of Psammomatous Melanotic Schwannoma is made using the following tools: Complete physical examination with thorough evaluation of the individuals medical history (including history of Carney complex) Neurological exam of the entire body Radiological studies (CT, MRI scan) of the affected region Nerve conduction studies of the affected nerve Other specific tests may be conducted based on the location of the tumor Tissue biopsy: A tissue biopsy is performed and sent to a laboratory for a pathological examination, who examines the biopsy under a microscope

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presented a case series on three adolescents who developed redness on the dorsal thenar spaces of both hands while being on doxycycline, coining the term heart sign given the shape of the affected areas when the hands are placed adjacent to one another [129]

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*Correspondence: Cesare Indiveri, [email protected] This article was submitted to Mitochondrial Research, a section of the journal Frontiers in Physiology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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