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Under normal physiological conditions, Nrf2 is sequestered by Keap1

van Staalduinen J, Baker D, Ten Dijke P, van Dam H

doi: 10.1152/ajpgi.00411.2015 102 DicksLMTDreyerLSmithCvan StadenAD

mollissima ) has coevolved with and has resistance to two major invasive pathogens , Cryphonectria parasitica and Phytophthora cinnamomi , both responsible for the complete demise of the susceptible American chestnut ( C

Epstein, Y

In line with human genetics findings, neurodegeneration occurs in the cerebellum and retina during aging in Harlequin mice that harbour a proviral insertion mutation in the intron 1 of Aifm1 leading to about 80% loss of AIF expression 13