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Most people following a varied diet get the recommended amount, but vegans, people with certain gut conditions and older adults who absorb nutrients less efficiently may need supplements

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Proc Natl Acad Sci USA 120:e2217864120

There was a significant change in both AHK-Cu and NTx

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However, it never received FDA approval because the results, while positive, weren't dramatic enough to meet regulatory thresholds for an obesity drug