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Research suggests that low serum 25-hydroxyvitamin D [25(OH)D] can lead to a 2-fold increase in the risk of joint space narrowing, a hallmark of advancing arthritis

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Horm Res 40 : 6267 Mauras N (1995) Combined recombinant human growth hormone and recombinant human insulin-like growth factor I: lack of synergy on whole body protein anabolism in normally fed subjects